HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DNMT1-RFD~ubiquitin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0008270 - zinc ion binding GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1616
+	Hs
		474933 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		475362 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Xl
		945540 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		P79922_XENLA (126-1616): 0: 1502: 70.07
+	Hs
		152818 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TRDMT_HUMAN (1138-1334): 3.1e-54: 197: 23.50
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (11-740): 2.09e-15: 84.8: 8.34
+	Hs
		476503 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		476584 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53
+	At
		1092242 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DRM2_ARATH (1090-1262): 3.7e-36: 149: 17.68