HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB5 (P28074)
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)
Gene: PSMB5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006979 - response to oxidative stress GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 263
+	Hs
		226590 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64
+	Hs
		228452 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82
+	Hs
		226565 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64
+	Hs
		226567 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22
+	Hs
		226730 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB10_HUMAN (44-248): 1.91e-78: 239: 27.32
+	Hs
		226592 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37
+	Hs
		474930 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64
+	Hs
		474931 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22
+	Hs
		475371 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB5_HUMAN (1-263): 2.38e-93: 277: 100.00
+	Hs
		475369 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64
+	At
		286456 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA4A_ARATH (32-263): 5.36e-86: 258: 17.21
+	Hs
		476251 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82
+	At
		188713 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSB5A_ARATH (5-263): 1.64e-82: 250: 55.17
+	At
		188702 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSB7A_ARATH (56-248): 2.27e-82: 249: 25.91
+	At
		188696 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA2A_ARATH (30-259): 2.5e-81: 245: 18.99
+	Hs
		475359 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64
+	At
		1091773 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA2B_ARATH (30-259): 1.72e-80: 243: 18.99
+	Hs
		475370 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37
+	At
		1091724 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSB7B_ARATH (11-249): 2.86e-72: 224: 25.11
+	At
		1091802 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSB6_ARATH (57-257): 5.03e-73: 224: 26.60