HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: GRN (P28799)
Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Gene: GRN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005794 - Golgi apparatus GO:0043524 - negative regulation of neuron apoptotic process GO:0050821 - protein stabilization GO:0051087 - protein-folding chaperone binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 593
+	Hs
		660739 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		GRN_HUMAN (1-593): 0: 726: 100.00
+	At
		794969 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RD21A_ARATH (444-514): 6.21e-17: 85.5: 32.47