HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ACSL1 (P33121)
Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)
Gene: ACSL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005783 - endoplasmic reticulum
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 698
+	Hs
		225993 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACSL4_HUMAN (25-693): 0: 592: 29.10
+	Hs
		226155 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACSL3_HUMAN (12-695): 0: 584: 29.20
+	Hs
		228304 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACSF2_HUMAN (33-689): 1.34e-137: 419: 18.42
+	At
		1091814 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		LACS6_ARATH (64-696): 0: 597: 40.99
+	Sc
		477356 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		LCF4_YEAST (56-695): 4.88e-171: 508: 25.83
+	At
		1092426 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		LACS4_ARATH (58-696): 0: 581: 36.10
+	Sc
		477375 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ACS2_YEAST (1-692): 2.34e-162: 485: 13.99
+	At
		82601 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACS_ARATH (26-692): 2.58e-162: 487: 13.19