HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ECHA (P40939)
Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
Gene: HADHA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0044877 - protein-containing complex binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 763
+	Hs
		778205 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		475443 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ECHA_HUMAN (1-763): 0: 942: 100.00
+	At
		1092445 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MFP2_ARATH (47-755): 0: 746: 30.97
+	At
		1092446 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AIM1_ARATH (46-756): 0: 721: 30.93
+	Hs
		227599 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HCDH_HUMAN (361-640): 4.08e-120: 365: 32.99
+	Hs
		227782 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HIBCH_HUMAN (1-365): 3.61e-97: 308: 17.46
+	Hs
		226616 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ECHM_HUMAN (1-292): 1.26e-79: 258: 24.83
+	Hs
		671475 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		ECHM_HUMAN (1-292): 1.26e-79: 258: 24.83
+	Hs
		227405 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AUHM_HUMAN (49-276): 1.58e-16: 83.6: 30.90