Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RAB7A (P51149)
Ras-related protein Rab-7a (EC 3.6.5.2)
Gene: RAB7A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.646

The method score is based on:

Property Details
Experiments 26911690, 35509820, 35256949
Identification Methods enzymatic study, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005739 - mitochondrion
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0045732 - positive regulation of protein catabolic process
GO:1903542 - negative regulation of exosomal secretion
and 1 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 465
Hs

1 207
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024