HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: KIF11 (P52732)
Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5)
Gene: KIF11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1056
+	Hs
		166351 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KIF3B_HUMAN (12-637): 2.35e-158: 488: 32.12
+	Hs
		229155 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KIF3A_HUMAN (8-617): 5.35e-126: 402: 34.25
+	Hs
		227290 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KIF1A_HUMAN (16-762): 1.22e-112: 385: 21.05
+	Hs
		226133 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KIF4A_HUMAN (11-465): 6.12e-60: 226: 37.11
+	Hs
		253241 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KI21B_HUMAN (16-1050): 9.69e-113: 385: 18.80
+	Hs
		227904 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KI21A_HUMAN (580-1051): 6.36e-12: 72.2: 8.92
+	Hs
		226654 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KINH_HUMAN (664-1051): 3.89e-10: 66.4: 9.51