HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 499
+	Hs
		227124 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		227015 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP4C_HUMAN (187-488): 7.07e-164: 467: 39.61
+	Hs
		227085 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	Hs
		226702 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		227059 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09
+	Hs
		227058 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Dm
		1214030 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		Q9VH81_DROME (4-494): 8.41e-179: 513: 59.60
+	Sc
		477136 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PP2A1_YEAST (162-488): 6.84e-165: 472: 35.67
+	Sc
		477137 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PP2A2_YEAST (164-482): 4.86e-162: 465: 35.00
+	Hs
		737883 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Sc
		477187 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PP12_YEAST (196-479): 9.87e-151: 434: 39.65
+	Hs
		475601 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		475582 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	At
		138691 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PP2A5_ARATH (185-481): 2.86e-161: 460: 37.92
+	Hs
		475568 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09
+	Hs
		475567 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	At
		990792 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PP2A3_ARATH (237-480): 8.16e-68: 221: 44.31
+	At
		820005 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PP2A4_ARATH (237-480): 3.06e-67: 220: 44.31
+	At
		990789 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PP2A1_ARATH (237-486): 4.96e-67: 219: 44.62