HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0098793 - presynapse
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 142
+	Hs
		228227 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54
+	Hs
		226996 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10
+	Hs
		228577 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		227052 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Hs
		228309 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Hs
		864088 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00
+	Hs
		1168532 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		474966 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00
+	Hs
		476314 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		475515 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00
+	Hs
		476177 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	At
		1091769 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPZ3_ARATH (1-139): 1.47e-42: 140: 17.48
+	At
		1091901 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPZ1_ARATH (2-140): 7.5e-41: 136: 16.08