HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 494
+	Hs
		226736 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP8_HUMAN (42-489): 9.27e-89: 295: 18.07
+	Hs
		226067 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP2_HUMAN (56-487): 5.71e-90: 288: 16.30
+	Hs
		474968 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		475523 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		271185 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP2_HUMAN (56-487): 5.71e-90: 288: 16.30
+	Hs
		1317098 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP21_HUMAN (29-486): 4.53e-88: 282: 16.80
+	Hs
		259291 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP12_HUMAN (61-484): 1.14e-95: 295: 18.49
+	Hs
		905386 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP46_HUMAN (61-483): 1.58e-95: 295: 18.76
+	Hs
		1168542 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP22_HUMAN (66-487): 1.12e-91: 290: 19.03
+	Hs
		474982 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP46_HUMAN (61-483): 1.58e-95: 295: 18.76
+	Sc
		477337 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	Hs
		271114 Q5U5U6_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP2_HUMAN (56-487): 5.71e-90: 288: 16.30
+	Hs
		476400 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP42_HUMAN (59-482): 3.47e-89: 299: 17.37
+	Hs
		259261 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP12_HUMAN (61-484): 1.14e-95: 295: 18.49
+	Hs
		475440 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP8_HUMAN (42-489): 9.27e-89: 295: 18.07
+	Hs
		475566 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP46_HUMAN (61-483): 1.58e-95: 295: 18.76
+	Hs
		64200 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP27_HUMAN (35-494): 3.18e-94: 294: 18.41
+	Hs
		271022 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP2_HUMAN (56-487): 5.71e-90: 288: 16.30
+	Hs
		475932 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		U17L2_HUMAN (82-492): 7.98e-90: 285: 19.37
+	Sc
		477366 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		UBP8_YEAST (105-485): 5.83e-38: 146: 20.51