HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: P5CS (P54886)
Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]
Gene: ALDH18A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 795
+	Zm
		14869 Q42415_MAIZE (1-153): 8.84e-50: 179: 20.13		A0A1D6G8E7_MAIZE (64-780): 0: 708: 42.49
+	Hs
		226248 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ALDH2_HUMAN (326-763): 3.36e-125: 386: 14.69
+	Hs
		226104 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL1A2_HUMAN (326-763): 1.02e-122: 380: 13.88
+	Hs
		226628 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL1B1_HUMAN (326-763): 3.11e-121: 376: 14.90
+	Hs
		226910 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL3A2_HUMAN (363-761): 5.3e-119: 369: 16.10
+	Sc
		477355 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ALDH2_YEAST (316-763): 1.33e-122: 379: 16.44
+	At
		1092390 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL2B4_ARATH (314-764): 8.63e-124: 384: 14.23
+	Hs
		475384 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AL1B1_HUMAN (326-763): 3.11e-121: 376: 14.90
+	Hs
		475850 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AL1L2_HUMAN (327-763): 1.92e-115: 373: 14.43
+	At
		1091706 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL2C4_ARATH (326-765): 1.31e-118: 369: 14.66
+	At
		1091722 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL3F1_ARATH (362-767): 2.44e-37: 148: 19.48