HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: AP1S2 (P56377)
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)
Gene: AP1S2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 157
+	Hs
		228227 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP3S1_HUMAN (1-143): 5.8e-49: 157: 36.91
+	Hs
		228577 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23
+	Hs
		228309 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Hs
		227052 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPZ1_HUMAN (1-154): 4.68e-41: 137: 19.87
+	Hs
		226953 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	Hs
		864088 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	Hs
		1168532 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23
+	Hs
		474966 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	Hs
		476314 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23
+	At
		1091769 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPZ3_ARATH (1-155): 1.26e-45: 148: 18.01
+	Hs
		476177 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Hs
		475515 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	At
		1091901 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPZ1_ARATH (1-155): 6.16e-40: 134: 18.63