HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PRPS1 (P60891)
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)
Gene: PRPS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	22792159, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 318
+	Mm
		1322079 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		PRPS1_MOUSE (1-318): 0: 507: 100.00
+	Hs
		225817 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPRB_HUMAN (3-318): 4.84e-137: 394: 44.00
+	Hs
		227452 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPRA_HUMAN (3-318): 6.17e-132: 381: 42.98
+	Hs
		474975 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PRPS1_HUMAN (1-318): 0: 507: 100.00
+	Hs
		475287 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRPS2_HUMAN (1-318): 7.43e-180: 500: 95.28
+	At
		1091689 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KPRS2_ARATH (3-313): 4.72e-147: 421: 45.51
+	At
		1091715 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KPRS4_ARATH (2-300): 4.35e-100: 299: 20.64