HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RL11 (P62913)
Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12)
Gene: RPL11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0031625 - ubiquitin protein ligase binding GO:0032092 - positive regulation of protein binding and 1 others more... GO:0050821 - protein stabilization
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 178
+	Hs
		312560 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RL11_HUMAN (1-178): 2.2e-91: 265: 100.00
+	Sc
		477510 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RL11B_YEAST (7-175): 1.98e-83: 245: 71.60
+	At
		791079 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RL111_ARATH (5-176): 6.32e-89: 259: 69.77
+	At
		791078 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RL112_ARATH (5-176): 1.17e-88: 258: 69.77
+	Zm
		79405 Q41754_MAIZE (1-76): 8.11e-30: 121: 31.58		B6SST7_MAIZE (4-144): 2.26e-55: 177: 25.83