HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25959826, 32929329, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0034599 - cellular response to oxidative stress
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 165
+	Hs
		226540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Rn
		88856 PRKN_RAT (1-465): 2.14e-136: 402: 85.16		D4A054_RAT (3-164): 2.91e-74: 243: 67.90
+	Hs
		226864 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67
+	Mm
		1322336 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		RBP2_MOUSE (3-164): 1.51e-73: 241: 67.28
+	At
		713361 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CP20C_ARATH (2-164): 5.46e-91: 267: 65.85
+	Hs
		203494 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PPIH_HUMAN (2-164): 1.38e-84: 247: 53.85