HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	35509820, 35256949, 25959826
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 377
+	Hs
		227018 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		227123 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		227131 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Hs
		227086 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTA_HUMAN (1-377): 0: 596: 98.41
+	Mm
		892218 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		ACTB_MOUSE (4-377): 0: 599: 94.12
+	Mm
		933097 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		ACTS_MOUSE (1-377): 0: 599: 98.94
+	Hs
		932245 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Hs
		475544 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		475603 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Hs
		475605 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Zm
		24703 A0A1D6IJX7_MAIZE (233-459): 1.19e-26: 116: 21.70		B4F989_MAIZE (1-377): 0: 592: 88.06