HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 29643511, 28710279, 30446597, 20089136, 21694720, 25375667, 24784582, 25583483, 25527291, 26746706, 26254304, 26387737, 26911690, 26116755, 19946270, 28414322, 27605430, 28945249, 28276439, 24647965 and 37 others

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Identification Methods pull down, enzymatic study, affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~ubiquitin, UQ_con~zf-RING_14
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 7 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 465
Hs

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Last updated: 15 Jul 2024