HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TBA1B (P68363)
Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]
Gene: TUBA1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	32929329, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 451
+	Hs
		228503 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA1C_HUMAN (1-451): 0: 728: 98.00
+	Hs
		227133 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA4A_HUMAN (1-450): 0: 719: 96.44
+	Hs
		227858 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA1A_HUMAN (1-440): 0: 715: 99.55
+	Hs
		228902 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBA8_HUMAN (1-440): 0: 701: 90.68
+	Hs
		226284 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		227134 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBB4B_HUMAN (1-437): 0: 697: 40.96
+	Hs
		1348225 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		TBA8_HUMAN (1-440): 0: 701: 90.68
+	Hs
		312567 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBA1B_HUMAN (1-440): 0: 717: 100.00
+	At
		1013212 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TBA4_ARATH (1-435): 0: 810: 85.98
+	At
		668104 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TBA6_ARATH (1-435): 0: 810: 85.75
+	Hs
		312449 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		312568 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TBB4B_HUMAN (1-437): 0: 697: 40.96
+	Hs
		475606 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TBA4A_HUMAN (1-450): 0: 719: 96.44
+	Hs
		475961 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TBA1A_HUMAN (1-440): 0: 715: 99.55