HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MAP1A (P78559)
Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]
Gene: MAP1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0015631 - tubulin binding GO:0043005 - neuron projection and 1 others more... GO:0070050 - neuron cellular homeostasis
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2803
+	Hs
		226795 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1B_HUMAN (886-2803): 6.87e-73: 275: 15.16
+	Hs
		226381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TPR_HUMAN (401-2740): 1.55e-57: 224: 8.84
+	Hs
		227833 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR87_HUMAN (695-1782): 1.13e-44: 182: 13.36
+	Hs
		227747 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1S_HUMAN (2163-2803): 4.97e-43: 175: 20.56
+	Hs
		228249 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SHIP1_HUMAN (2297-2702): 1.65e-39: 164: 16.67
+	Hs
		227434 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DCTN1_HUMAN (1206-1677): 2.47e-36: 153: 16.80
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (139-1866): 7.45e-22: 107: 10.64
+	Hs
		229078 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRRM2_HUMAN (1736-2728): 3.76e-19: 98: 10.66
+	Hs
		227627 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRDN_HUMAN (1320-1644): 2.84e-12: 75.3: 20.47
+	Hs
		229173 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRC2C_HUMAN (861-2729): 1.2e-11: 73.4: 7.65
+	Hs
		227460 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MDC1_HUMAN (1591-2710): 3.27e-11: 71.8: 10.03
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (2245-2733): 3.71e-11: 71.8: 10.59
+	Hs
		475816 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ITSN1_HUMAN (1332-1930): 3.27e-43: 177: 13.88
+	Hs
		475874 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TGO1_HUMAN (342-2093): 3.41e-35: 150: 10.19
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (2176-2722): 4.38e-33: 144: 13.60
+	Hs
		234177 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PEPL_HUMAN (1352-1705): 1.35e-10: 69.5: 19.84
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (1735-2150): 1.47e-09: 66.3: 12.26