HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: BAX (Q07812)
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Gene: BAX

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

The method score is based on:

Property	Details
Experiments	28760928, 32929329
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005783 - endoplasmic reticulum and 6 others more... GO:0005829 - cytosol GO:0030544 - Hsp70 protein binding GO:0034620 - cellular response to unfolded protein GO:0042981 - regulation of apoptotic process GO:0043524 - negative regulation of neuron apoptotic process GO:0051881 - regulation of mitochondrial membrane potential
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	192

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024