HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TBL3 (Q12788)
Transducin beta-like protein 3 (WD repeat-containing protein SAZD)
Gene: TBL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 808
+	Hs
		152845 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		APAF_HUMAN (329-768): 5.07e-68: 247: 16.46
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (458-757): 3.76e-66: 225: 20.93
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (469-761): 8.84e-59: 209: 13.35
+	Hs
		228157 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GEMI5_HUMAN (234-739): 6.31e-54: 205: 12.88
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (454-648): 1.4e-52: 190: 25.13
+	Hs
		226026 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR1_HUMAN (474-761): 5.72e-34: 140: 12.08
+	Hs
		229023 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBW1B_HUMAN (334-646): 6.06e-24: 108: 24.46
+	Hs
		229098 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBW1A_HUMAN (334-642): 7.67e-24: 108: 26.17
+	Hs
		229068 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR3_HUMAN (2-94): 8.52e-16: 84.1: 10.64
+	Hs
		227540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TAF5_HUMAN (74-224): 5.48e-11: 68.2: 25.17
+	Hs
		1356385 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBW1B_HUMAN (334-646): 6.06e-24: 108: 24.46
+	Hs
		1377165 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBW1A_HUMAN (334-642): 7.67e-24: 108: 26.17
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (458-757): 3.76e-66: 225: 20.93
+	At
		1277191 ARI1_ARATH (221-461): 1.48e-61: 212: 20.73		TPL_ARATH (525-767): 1.46e-13: 76.7: 8.88
+	At
		1013240 ARI1_ARATH (221-461): 1.48e-61: 212: 20.73		TPR1_ARATH (1-180): 8.39e-10: 64.8: 12.06
+	Hs
		476547 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBW1B_HUMAN (334-646): 6.06e-24: 108: 24.46
+	Hs
		476595 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBW1A_HUMAN (334-642): 7.67e-24: 108: 26.17
+	At
		1092188 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		GPLPC_ARATH (306-592): 2.08e-10: 65.1: 23.59
+	At
		1013223 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TPR1_ARATH (1-180): 8.39e-10: 64.8: 12.06
+	At
		1091956 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		GPLPB_ARATH (52-284): 9.87e-09: 59.7: 23.55