HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: GRIK2 (Q13002)
Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
Gene: GRIK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25316086
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030165 - PDZ domain binding GO:0031624 - ubiquitin conjugating enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0035249 - synaptic transmission, glutamatergic GO:0043524 - negative regulation of neuron apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 908
+	Mm
		761223 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		GRIK2_MOUSE (1-908): 0: 960: 99.01
+	Hs
		226753 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIA1_HUMAN (15-854): 0: 763: 39.46
+	Hs
		227565 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIK4_HUMAN (14-876): 0: 717: 43.46
+	Hs
		227573 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIK5_HUMAN (20-902): 0: 704: 43.83
+	Hs
		227241 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NMDZ1_HUMAN (11-906): 0: 603: 23.20
+	Hs
		203179 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRID2_HUMAN (12-907): 0: 602: 26.76