HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CDC16 (Q13042)
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)
Gene: CDC16

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0070979 - protein K11-linked ubiquitination
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 620
+	Hs
		1022935 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		CDC16_HUMAN (1-620): 1.68e-124: 382: 100.00
+	Hs
		227803 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTR9_HUMAN (96-617): 5.62e-29: 125: 10.36
+	Hs
		174471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67
+	Dm
		1180619 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		Q7KJA9_DROME (3-350): 1.73e-50: 190: 11.94
+	Hs
		229015 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73
+	Hs
		229014 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71
+	Hs
		226620 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80
+	Hs
		227849 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TMTC3_HUMAN (2-201): 8.27e-11: 67.1: 11.98
+	Dm
		284375 ARI2_DROME (228-464): 7.29e-69: 229: 20.92		Q7KJA9_DROME (3-350): 1.73e-50: 190: 11.94
+	Hs
		1219389 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73
+	Hs
		1219388 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71
+	Hs
		672859 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80
+	Hs
		174509 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67
+	Hs
		672852 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80
+	Hs
		174570 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67
+	Hs
		476163 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TTC28_HUMAN (269-611): 9.74e-25: 112: 13.89
+	Hs
		476539 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73
+	Hs
		475381 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80