HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.915

The method score is based on:

Property Details
Experiments 25959826, 35509820, 35256949, 20810900, 23503661
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PC_rep~ubiquitin
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 465
Hs

1 908
+ Hs
+ At
+ At
+ Hs
+ Sc
+ Hs
+ At
+ At
+ Sc
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024