HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 0.60 0.696

The method score is based on:

Property Details
Experiments 26746706, 26364802, 35256949, 23503661
Identification Methods affinity chromatography technology, pull down, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000422 - autophagy of mitochondrion
GO:0000423 - mitophagy
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
and 14 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 465
Hs

1 440
+ Hs
+ Hs
+ Hs
+ Xl
+ Dr
+ Hs
+ Dr
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024