HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2472
+	Hs
		164537 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		227192 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		227471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		227506 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		228808 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SPTN5_HUMAN (1344-2417): 7.31e-16: 87: 15.00
+	Hs
		226387 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211433 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		1313544 AKIB1_HUMAN (238-456): 1.26e-60: 215: 21.55		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		475174 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		475789 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		476576 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48