HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0015631 - tubulin binding GO:0044877 - protein-containing complex binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2115
+	Hs
		475773 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		226679 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		226680 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		227506 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		227500 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15
+	Hs
		226691 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41
+	Hs
		227471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GOGB1_HUMAN (1105-2077): 1.12e-19: 99.3: 9.49
+	Hs
		226381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Hs
		227368 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GOGA4_HUMAN (5-528): 2.18e-12: 75: 11.24
+	Hs
		1313544 AKIB1_HUMAN (238-456): 1.26e-60: 215: 21.55		CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08
+	Hs
		475174 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08
+	Hs
		475644 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63
+	At
		98522 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CIP1_ARATH (738-1825): 4.92e-41: 168: 12.61
+	Hs
		475291 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MYH1_HUMAN (1-831): 3.6e-35: 150: 12.27
+	Hs
		475417 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		475789 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37