HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	35509820, 35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RPN7~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 389
+	Hs
		227323 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN1_HUMAN (12-389): 3.49e-93: 289: 20.25
+	Hs
		227037 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN2_HUMAN (22-388): 5.37e-90: 280: 13.67
+	Hs
		121640 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		227012 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EIF3E_HUMAN (26-387): 7.71e-74: 238: 14.04
+	Hs
		475779 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Sc
		477452 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	At
		1091885 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSMD6_ARATH (12-389): 8.46e-116: 343: 53.95
+	At
		799469 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CSN1_ARATH (17-389): 2.68e-95: 293: 19.47
+	Hs
		475555 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN2_HUMAN (22-388): 5.37e-90: 280: 13.67
+	Sc
		477496 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57
+	Hs
		121666 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	At
		1092149 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD11_ARATH (7-388): 4e-73: 235: 11.75