HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck GO:1903377 - negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 471
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		228197 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (66-459): 5.94e-61: 211: 13.88
+	Hs
		226538 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		227552 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Hs
		227669 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1M_HUMAN (75-214): 4.77e-36: 134: 27.27
+	Hs
		228318 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP5_HUMAN (78-205): 4.72e-26: 111: 26.76
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (7-161): 7.22e-16: 82.3: 18.24
+	Hs
		228568 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		474924 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		475340 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		475809 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (29-411): 6.59e-40: 154: 14.56
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (143-368): 1.41e-11: 68.8: 14.54