HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SC23A (Q15436)
Protein transport protein Sec23A (hSec23A) (SEC23-related protein A)
Gene: SEC23A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 765
+	Hs
		227537 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC23B_HUMAN (1-764): 0: 1061: 84.73
+	Hs
		1073966 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		SC23A_HUMAN (1-765): 0: 1079: 100.00
+	Hs
		475802 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SC23B_HUMAN (1-764): 0: 1061: 84.73
+	At
		1092180 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC23E_ARATH (10-763): 0: 949: 48.69
+	At
		1091761 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC23B_ARATH (12-763): 0: 938: 46.92
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (2-758): 0: 573: 16.96
+	Hs
		226154 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24B_HUMAN (6-758): 0: 567: 17.48
+	Hs
		226153 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24A_HUMAN (5-758): 0: 561: 17.59
+	At
		1092237 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24B_ARATH (3-718): 0: 573: 16.47
+	At
		1092229 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24C_ARATH (2-727): 0: 569: 17.04
+	At
		1092316 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24A_ARATH (3-665): 5.5e-167: 510: 16.95