HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SF3A1 (Q15459)
Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)
Gene: SF3A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 793
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (293-702): 3.81e-38: 156: 16.70
+	Hs
		227108 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RL40_HUMAN (722-790): 6.93e-24: 99.4: 30.44
+	Hs
		227107 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RS27A_HUMAN (722-790): 7.14e-21: 92: 30.44
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (262-745): 2.99e-20: 98.8: 11.85
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (306-661): 8.33e-15: 81.3: 14.72
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (429-746): 1.82e-09: 63.7: 13.13
+	At
		95174 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		F4HW92_ARATH (1-756): 8.61e-85: 287: 29.71
+	Hs
		474985 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RL40_HUMAN (722-790): 6.93e-24: 99.4: 30.44
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (120-749): 9.99e-30: 129: 8.18
+	Hs
		152577 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KMT2D_HUMAN (538-699): 7.37e-26: 117: 22.35
+	Hs
		475591 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RL40_HUMAN (722-790): 6.93e-24: 99.4: 30.44
+	Dm
		574862 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		RL40_DROME (722-790): 6.93e-24: 99.4: 30.44
+	Hs
		475590 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RS27A_HUMAN (722-790): 7.14e-21: 92: 30.44
+	At
		1092229 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24C_ARATH (411-746): 4.18e-10: 65.5: 12.64
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (469-771): 2.31e-09: 63.3: 14.10