HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SMU1 (Q2TAY7)
WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]
Gene: SMU1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 513
+	Hs
		228711 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR26_HUMAN (3-513): 2.59e-99: 314: 19.45
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (4-472): 9.67e-90: 282: 15.13
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (78-425): 2.83e-76: 245: 21.25
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (252-512): 4.37e-62: 213: 16.96
+	Hs
		475845 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SMU1_HUMAN (1-513): 7.53e-153: 447: 100.00
+	Hs
		228745 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB4_HUMAN (323-511): 2.27e-26: 111: 21.47
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (433-513): 1.02e-23: 106: 23.46
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (18-240): 3.64e-24: 105: 10.50
+	Hs
		227099 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB2_HUMAN (187-335): 1.43e-21: 97.7: 20.81
+	Hs
		228555 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KTNB1_HUMAN (154-383): 2.6e-11: 68.2: 24.26
+	Hs
		227122 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RACK1_HUMAN (277-377): 7.24e-11: 65.5: 33.33
+	Hs
		227292 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL3_HUMAN (213-376): 4.84e-09: 60.8: 24.55
+	Hs
		476385 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR26_HUMAN (3-513): 2.59e-99: 314: 19.45
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (18-240): 3.64e-24: 105: 10.50
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (78-425): 2.83e-76: 245: 21.25
+	Hs
		1334930 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		GBB4_HUMAN (323-511): 2.27e-26: 111: 21.47
+	Hs
		476404 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GBB4_HUMAN (323-511): 2.27e-26: 111: 21.47
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (18-240): 3.64e-24: 105: 10.50
+	Hs
		475589 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GBB2_HUMAN (187-335): 1.43e-21: 97.7: 20.81