HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: EIPR1 (Q53HC9)
EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein)
Gene: EIPR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016567 - protein ubiquitination GO:1905281 - positive regulation of retrograde transport, endosome to Golgi
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 387
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (214-387): 1.22e-43: 156: 18.38
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (2-211): 9.99e-29: 116: 6.90
+	Hs
		227583 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP7_HUMAN (227-386): 1.08e-24: 106: 14.14
+	Hs
		227278 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP4_HUMAN (2-167): 3.81e-21: 96: 12.65
+	Hs
		228498 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRWD1_HUMAN (219-379): 2.74e-19: 90.9: 14.63
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (299-383): 3.76e-17: 84.8: 8.33
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (3-87): 2.4e-10: 64: 14.12
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (2-211): 9.99e-29: 116: 6.90
+	Hs
		312590 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RBBP4_HUMAN (2-167): 3.81e-21: 96: 12.65
+	Hs
		312654 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		GRWD1_HUMAN (219-379): 2.74e-19: 90.9: 14.63
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (214-387): 1.22e-43: 156: 18.38
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (2-211): 9.99e-29: 116: 6.90
+	Hs
		475670 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RBBP4_HUMAN (2-167): 3.81e-21: 96: 12.65
+	Hs
		476280 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GRWD1_HUMAN (219-379): 2.74e-19: 90.9: 14.63