HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 376
+	Hs
		227018 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		227123 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTG_HUMAN (3-376): 0: 595: 91.44
+	Hs
		227128 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTC_HUMAN (2-376): 0: 590: 88.27
+	Hs
		227131 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTS_HUMAN (2-376): 0: 590: 87.47
+	Hs
		227086 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTA_HUMAN (1-376): 0: 588: 87.80
+	Mm
		892218 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		ACTB_MOUSE (3-376): 0: 596: 91.71
+	Mm
		933097 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		ACTS_MOUSE (2-376): 0: 590: 87.47
+	Hs
		932245 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		ACTC_HUMAN (2-376): 0: 590: 88.27
+	Sc
		477407 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ACT_YEAST (1-376): 0: 585: 82.98
+	Hs
		475544 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		475603 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACTC_HUMAN (2-376): 0: 590: 88.27
+	Hs
		475605 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACTS_HUMAN (2-376): 0: 590: 87.47