HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ZN598 (Q86UK7)
E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)
Gene: ZNF598

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006513 - protein monoubiquitination GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 904
+	Hs
		228767 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAGE1_HUMAN (269-656): 6.73e-15: 81.6: 15.10
+	Hs
		227885 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MICA3_HUMAN (254-891): 3.53e-13: 76: 10.97
+	Hs
		226474 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SON_HUMAN (339-771): 7.47e-12: 72: 12.39
+	Hs
		226120 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC31A_HUMAN (305-642): 1.99e-11: 70.2: 11.77
+	Hs
		227747 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1S_HUMAN (261-689): 3.83e-11: 69.3: 17.00
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (276-600): 5.48e-11: 69: 9.17
+	At
		96433 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		F4IK68_ARATH (28-523): 1.14e-106: 348: 20.72
+	Hs
		228101 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KMT2C_HUMAN (243-831): 8.09e-10: 65.2: 8.37
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (267-885): 1.86e-09: 64: 6.60
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (216-627): 1.06e-10: 67.9: 10.68
+	Hs
		302333 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SC31A_HUMAN (305-642): 1.99e-11: 70.2: 11.77
+	Rn
		94376 HOIL1_RAT (12-448): 8.73e-66: 221: 17.05		F1M9G7_RAT (248-742): 1.22e-10: 67.8: 9.89
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (262-897): 7.33e-20: 97.9: 9.25
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (547-899): 2.92e-13: 76.3: 9.33
+	Hs
		302245 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SC31A_HUMAN (305-642): 1.99e-11: 70.2: 11.77
+	At
		1092229 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24C_ARATH (288-630): 4.05e-09: 62.7: 11.26