HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ULK2 (Q8IYT8)
Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)
Gene: ULK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1036
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (8-805): 2.13e-136: 432: 19.88
+	Hs
		262227 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ULK1_HUMAN (2-1029): 0: 709: 49.02
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (8-696): 1.77e-128: 410: 20.86
+	Hs
		228811 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNRK_HUMAN (9-689): 1.54e-125: 402: 19.08
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (3-339): 2.97e-127: 397: 23.12
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (3-342): 3.7e-126: 394: 24.29
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (3-342): 3.7e-126: 394: 24.29
+	Sc
		419769 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SNF1_YEAST (9-462): 8.95e-128: 404: 23.50
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (3-339): 2.97e-127: 397: 23.12
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (3-342): 3.7e-126: 394: 24.29
+	Hs
		228597 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK33_HUMAN (9-222): 9.52e-40: 157: 38.99
+	Hs
		270450 RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62		KS6A5_HUMAN (2-735): 4.69e-133: 423: 15.05
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (8-369): 4.36e-132: 411: 25.61
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (8-366): 1.44e-129: 404: 24.45
+	At
		1091676 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK3_ARATH (1-357): 8.85e-128: 400: 25.49
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (3-342): 3.7e-126: 394: 24.29
+	Hs
		1161519 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		ULK3_HUMAN (15-279): 5.92e-53: 194: 39.71
+	Hs
		475928 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ULK3_HUMAN (15-279): 5.92e-53: 194: 39.71