HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RPTOR (Q8N122)
Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Gene: RPTOR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25007995, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010506 - regulation of autophagy GO:0019901 - protein kinase binding GO:0044877 - protein-containing complex binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1335
+	Hs
		228276 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (1059-1334): 3.26e-59: 215: 12.50
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (1101-1334): 4.69e-55: 199: 15.69
+	Hs
		227233 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TLE3_HUMAN (1165-1335): 2.38e-23: 109: 13.07
+	Hs
		228464 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI3R4_HUMAN (1102-1335): 7.12e-19: 95.3: 13.78
+	Hs
		228555 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KTNB1_HUMAN (1110-1332): 6.73e-18: 91.4: 23.21
+	Hs
		1281514 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (1246-1335): 6.58e-16: 82.9: 17.58
+	Hs
		226681 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPB2_HUMAN (1197-1333): 5.9e-15: 82.2: 15.83
+	Hs
		226950 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPA_HUMAN (1009-1182): 1.34e-10: 68.3: 17.62
+	Hs
		476151 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (1246-1335): 6.58e-16: 82.9: 17.58
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Hs
		863478 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		COPA_HUMAN (1009-1182): 1.34e-10: 68.3: 17.62
+	Sc
		477274 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		KOG1_YEAST (1087-1332): 1.64e-15: 84.5: 12.36
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (1246-1335): 6.58e-16: 82.9: 17.58