HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NUP43 (Q8NFH3)
Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42)
Gene: NUP43

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35987950
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 380
+	Hs
		228276 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBXW7_HUMAN (3-371): 2.85e-70: 235: 12.30
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (3-289): 4.3e-58: 193: 14.24
+	Hs
		228498 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRWD1_HUMAN (68-330): 6.16e-56: 191: 15.84
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (5-248): 1.25e-48: 171: 12.06
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (249-378): 1.1e-25: 107: 17.04
+	Hs
		196917 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRP4_HUMAN (215-379): 1.68e-23: 103: 17.71
+	Hs
		228623 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR33_HUMAN (173-376): 7.97e-20: 93.6: 16.51
+	Hs
		227278 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP4_HUMAN (216-378): 3.53e-19: 90.3: 13.59
+	Hs
		227583 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP7_HUMAN (216-378): 1.89e-18: 88.3: 14.13
+	Hs
		1281514 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBXW7_HUMAN (3-371): 2.85e-70: 235: 12.30
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (3-100): 1.12e-09: 61.7: 9.09
+	Hs
		312654 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		GRWD1_HUMAN (68-330): 6.16e-56: 191: 15.84
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (249-378): 1.1e-25: 107: 17.04
+	Hs
		476068 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NUP43_HUMAN (1-380): 6.08e-77: 243: 95.80
+	Hs
		476151 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBXW7_HUMAN (3-371): 2.85e-70: 235: 12.30
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (3-289): 4.3e-58: 193: 14.24
+	Hs
		312590 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RBBP4_HUMAN (216-378): 3.53e-19: 90.3: 13.59
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (249-378): 1.1e-25: 107: 17.04
+	Hs
		196947 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRP4_HUMAN (215-379): 1.68e-23: 103: 17.71
+	Hs
		475670 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RBBP4_HUMAN (216-378): 3.53e-19: 90.3: 13.59