HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PI42C (Q8TBX8)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)
Gene: PIP4K2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0010506 - regulation of autophagy
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 421
+	Hs
		227142 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI42B_HUMAN (3-420): 5.99e-159: 456: 63.66
+	Hs
		228480 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI51A_HUMAN (11-418): 1.17e-151: 442: 29.57
+	Hs
		226812 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI42A_HUMAN (1-420): 1.73e-153: 441: 61.94
+	Hs
		1306336 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		PI51A_HUMAN (11-418): 1.17e-151: 442: 29.57
+	Hs
		231370 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PI51C_HUMAN (8-418): 4.04e-152: 447: 29.76
+	At
		1092313 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PI5K6_ARATH (34-420): 6.71e-147: 436: 26.78
+	At
		1091827 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PI5K8_ARATH (41-420): 1.47e-132: 400: 27.15