HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NEK9 (Q8TD19)
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
Gene: NEK9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 979
+	Hs
		1168524 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		NEK9_HUMAN (1-979): 0: 1056: 100.00
+	Hs
		476090 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEK9_HUMAN (1-979): 0: 1056: 100.00
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (2-481): 1.57e-137: 432: 20.00
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (1-446): 1.65e-131: 417: 19.91
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (6-380): 2.11e-129: 401: 21.52
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (29-485): 3.87e-126: 393: 22.17
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	Hs
		227797 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK5_HUMAN (52-308): 3.87e-57: 212: 40.70
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (6-380): 2.11e-129: 401: 21.52
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	Hs
		226921 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK2_HUMAN (45-334): 6.31e-52: 191: 36.84
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (29-485): 3.87e-126: 393: 22.17
+	Hs
		228149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK7_HUMAN (58-304): 2.53e-48: 176: 39.29
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (51-369): 1.64e-127: 397: 23.99
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (27-411): 5.87e-127: 395: 20.36
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (35-416): 9.75e-127: 395: 21.35
+	Hs
		475987 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEK8_HUMAN (618-802): 9.67e-25: 112: 16.84
+	Hs
		475785 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HERC3_HUMAN (621-763): 1.47e-15: 83.8: 15.86