HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSPC1 (Q8WXF1)
Paraspeckle component 1 (Paraspeckle protein 1)
Gene: PSPC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 523
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		227511 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (4-522): 2.67e-63: 219: 13.06
+	Hs
		226538 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		228318 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP5_HUMAN (86-416): 1.38e-52: 184: 16.90
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (3-149): 2.52e-27: 118: 18.83
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (3-149): 5.8e-27: 116: 18.83
+	Hs
		227552 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		228568 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBM4_HUMAN (83-190): 4.98e-09: 60.1: 32.14
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		474924 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (3-149): 2.52e-27: 118: 18.83
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		475340 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (4-397): 2.67e-45: 170: 14.18
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (3-149): 2.52e-27: 118: 18.83
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (2-149): 4.38e-24: 108: 16.03
+	Hs
		475809 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11