HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: AP3S1 (Q92572)
AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)
Gene: AP3S1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0098793 - presynapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 193
+	Hs
		226996 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP1S2_HUMAN (2-158): 5.07e-50: 160: 35.03
+	Hs
		228309 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP2M1_HUMAN (1-186): 6.1e-47: 160: 11.83
+	Hs
		229113 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP3M1_HUMAN (1-188): 1.37e-44: 154: 18.09
+	Hs
		227052 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPZ1_HUMAN (2-166): 7.56e-45: 148: 22.02
+	Hs
		226953 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP2S1_HUMAN (1-148): 1.73e-43: 143: 40.54
+	Hs
		864088 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		AP2S1_HUMAN (1-148): 1.73e-43: 143: 40.54
+	Hs
		1168543 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		AP3M1_HUMAN (1-188): 1.37e-44: 154: 18.09
+	Hs
		474966 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AP2S1_HUMAN (1-148): 1.73e-43: 143: 40.54
+	Hs
		476177 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2M1_HUMAN (1-186): 6.1e-47: 160: 11.83
+	At
		1091769 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPZ3_ARATH (1-160): 5.8e-47: 153: 22.16
+	At
		1091901 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPZ1_ARATH (2-160): 7.48e-45: 148: 19.28
+	Hs
		475515 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2S1_HUMAN (1-148): 1.73e-43: 143: 40.54