HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: GCN1 (Q92616)
Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
Gene: GCN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32929329
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 2671
+	Hs
		1268276 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		GCN1_HUMAN (1-2671): 0: 2129: 100.00
+	Hs
		226063 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SF3B1_HUMAN (1238-2069): 1.02e-61: 236: 13.97
+	Hs
		228265 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TNPO1_HUMAN (908-1705): 1.2e-50: 198: 13.59
+	Hs
		127137 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18
+	Hs
		226755 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTOR_HUMAN (824-2632): 3.31e-34: 147: 12.46
+	Sc
		477401 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		EF3B_YEAST (1372-1700): 5.42e-91: 324: 27.38
+	Sc
		477108 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		EF3A_YEAST (1372-1754): 2.38e-85: 307: 24.24
+	Hs
		227939 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Hs
		226619 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	Hs
		227413 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CKAP5_HUMAN (953-1968): 8.99e-11: 70.1: 10.33
+	Hs
		227734 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ECM29_HUMAN (1769-2544): 4.52e-09: 64.6: 12.24
+	Hs
		312492 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	At
		95900 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ILA_ARATH (866-2657): 3.33e-46: 187: 12.09
+	Hs
		127169 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18
+	Hs
		475380 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		2AAB_HUMAN (2265-2670): 2.67e-36: 149: 14.67
+	Hs
		475451 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MTOR_HUMAN (824-2632): 3.31e-34: 147: 12.46
+	At
		1091631 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		2AAA_ARATH (947-1565): 3.62e-27: 121: 13.69
+	Hs
		476002 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Hs
		475379 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		2AAA_HUMAN (959-1405): 1.51e-19: 97.8: 12.22
+	At
		1091638 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		2AAB_ARATH (1025-1373): 1.58e-13: 78.2: 13.90