HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: B2CL2 (Q92843)
Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
Gene: BCL2L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24999239
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0042981 - regulation of apoptotic process GO:0044877 - protein-containing complex binding GO:0090201 - negative regulation of release of cytochrome c from mitochondria
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 193
+	Hs
		226341 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BCL2_HUMAN (9-193): 1.75e-61: 192: 35.32
+	Mm
		489505 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		BCL2_MOUSE (4-193): 2.66e-63: 197: 41.58
+	Hs
		227261 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		B2CL1_HUMAN (6-185): 1.44e-56: 179: 38.96
+	Hs
		227262 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCL1_HUMAN (19-180): 6.36e-46: 156: 21.82
+	Hs
		227260 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BAX_HUMAN (11-178): 5.55e-40: 136: 20.71
+	Mm
		992064 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		BAX_MOUSE (11-178): 1.8e-40: 137: 21.89
+	Hs
		475006 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		B2CL1_HUMAN (6-185): 1.44e-56: 179: 38.96