HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TNPO1 (Q92973)
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Gene: TNPO1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 898
+	Hs
		127137 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IPO5_HUMAN (21-879): 2.71e-91: 314: 16.85
+	Hs
		227476 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMB1_HUMAN (21-862): 1.01e-87: 300: 16.15
+	Hs
		226978 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		XPO2_HUMAN (14-897): 9.98e-87: 299: 12.98
+	At
		1091763 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TNPO1_ARATH (9-895): 3.03e-161: 496: 43.70
+	Sc
		477453 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		IMB1_YEAST (22-840): 2.35e-87: 299: 16.04
+	At
		1092036 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IMB1_ARATH (19-873): 2.06e-97: 326: 15.33
+	Hs
		127169 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IPO5_HUMAN (21-879): 2.71e-91: 314: 16.85
+	Hs
		475772 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IMB1_HUMAN (21-862): 1.01e-87: 300: 16.15
+	Hs
		312165 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IPO7_HUMAN (21-851): 6.08e-77: 273: 14.49
+	At
		1091872 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q93VS8_ARATH (15-896): 3.83e-32: 137: 11.52
+	At
		1091859 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q8W498_ARATH (167-895): 3.5e-22: 105: 16.56