HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 32929329, 35509820, 35256949
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains UBA_4~ubiquitin
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0031625 - ubiquitin protein ligase binding
GO:0036503 - ERAD pathway
GO:0043130 - ubiquitin binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 465
Hs

1 445
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024