HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	35256949, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Peptidase_C65~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043130 - ubiquitin binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 271
+	Hs
		475135 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		476193 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		1288089 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		OTUB2_HUMAN (47-270): 1.25e-104: 305: 47.77
+	Hs
		476180 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTUB2_HUMAN (47-270): 1.25e-104: 305: 47.77