HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FUBP3 (Q96I24)
Far upstream element-binding protein 3 (FUSE-binding protein 3)
Gene: FUBP3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 572
+	Hs
		228295 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FUBP1_HUMAN (16-565): 1.97e-104: 329: 52.53
+	Hs
		228262 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FUBP2_HUMAN (14-558): 1.18e-101: 324: 41.53
+	Hs
		127952 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IF2B3_HUMAN (237-560): 9.9e-32: 131: 14.15
+	Hs
		228921 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IF2B1_HUMAN (237-560): 7.9e-26: 113: 15.69
+	Hs
		227521 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCBP2_HUMAN (6-331): 5.08e-23: 102: 16.24
+	Hs
		227055 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HNRPK_HUMAN (242-475): 5.55e-18: 88.8: 15.26
+	Hs
		229223 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IF2B2_HUMAN (233-445): 1.04e-12: 72.6: 18.14
+	Hs
		227520 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCBP1_HUMAN (21-151): 5.83e-13: 72.3: 23.88
+	Hs
		476143 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FUBP2_HUMAN (14-558): 1.18e-101: 324: 41.53
+	Hs
		1072089 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		PCBP1_HUMAN (21-151): 5.83e-13: 72.3: 23.88
+	Hs
		312534 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HNRPK_HUMAN (242-475): 5.55e-18: 88.8: 15.26
+	Hs
		128003 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IF2B3_HUMAN (237-560): 9.9e-32: 131: 14.15
+	Hs
		475796 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PCBP2_HUMAN (6-331): 5.08e-23: 102: 16.24
+	Hs
		475564 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HNRPK_HUMAN (242-475): 5.55e-18: 88.8: 15.26