HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBP47 (Q96K76)
Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47)
Gene: USP47

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 1375
+	Hs
		228270 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP7_HUMAN (12-920): 6.66e-135: 444: 20.15
+	Hs
		131632 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		USP9Y_HUMAN (2-682): 2.62e-90: 326: 16.13
+	Hs
		228269 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		USP9X_HUMAN (2-831): 5.16e-90: 325: 14.39
+	Hs
		226067 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP2_HUMAN (45-489): 4.34e-94: 318: 18.11
+	Hs
		1273850 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP7_HUMAN (12-920): 6.66e-135: 444: 20.15
+	Hs
		475123 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP7_HUMAN (12-920): 6.66e-135: 444: 20.15
+	Hs
		1168542 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP22_HUMAN (23-569): 7.33e-115: 372: 15.46
+	Hs
		1119479 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		PAN2_HUMAN (100-793): 3.64e-92: 326: 12.97
+	Hs
		271185 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP2_HUMAN (45-489): 4.34e-94: 318: 18.11
+	Sc
		477365 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		UBP15_YEAST (43-708): 7.68e-91: 323: 21.29
+	Hs
		271114 Q5U5U6_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP2_HUMAN (45-489): 4.34e-94: 318: 18.11
+	Hs
		475082 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP48_HUMAN (172-668): 2.23e-89: 315: 21.20
+	Mm
		476669 UBB_MOUSE (1-152): 5.65e-49: 171: 19.61		UBP48_MOUSE (172-668): 3.24e-88: 312: 21.54
+	Hs
		475952 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP34_HUMAN (123-601): 6.66e-92: 331: 21.27
+	Hs
		64200 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP27_HUMAN (125-576): 6.88e-100: 328: 17.28
+	Hs
		131635 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		USP9Y_HUMAN (2-682): 2.62e-90: 326: 16.13
+	Hs
		271022 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP2_HUMAN (45-489): 4.34e-94: 318: 18.11
+	Hs
		475995 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP48_HUMAN (172-668): 2.23e-89: 315: 21.20
+	Hs
		475932 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		U17L2_HUMAN (130-620): 1.87e-91: 308: 19.25
+	Hs
		475954 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP31_HUMAN (186-343): 2.88e-32: 139: 18.59