HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ASB2 (Q96Q27)
Ankyrin repeat and SOCS box protein 2 (ASB-2)
Gene: ASB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0097602 - cullin family protein binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 635
+	Hs
		227310 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANK3_HUMAN (2-356): 3.48e-96: 326: 21.41
+	Hs
		476231 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ASB2_HUMAN (1-635): 4.32e-159: 472: 100.00
+	Hs
		228203 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ASB15_HUMAN (239-568): 8.71e-48: 178: 17.16
+	Hs
		227985 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANKH1_HUMAN (3-171): 1.59e-23: 108: 11.83
+	Hs
		229176 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ASB3_HUMAN (412-568): 1.18e-15: 81.9: 15.66
+	Hs
		312683 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		ASB3_HUMAN (412-568): 1.18e-15: 81.9: 15.66
+	Hs
		476024 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ANKH1_HUMAN (3-171): 1.59e-23: 108: 11.83
+	Hs
		476634 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ASB3_HUMAN (412-568): 1.18e-15: 81.9: 15.66